January 2018. Fratagene Therapeutics to present new drug discovery strategies for Friedreich ataxia at the Keystone Symposia "Ubiquitin Signaling", Tahoe City, CA, USA, January 28 - February 1.
November 2017. Fratagene Therapeutics invited by the European Research Council to present its discovery programs at the Slush, the world’s leading venturing event for startups to be held in Helsinki, November 29 - December 1, during the Slush y Science vertical.
September 2017. Fratagene Therapeutics to present exciting new findings at the International Ataxia Research Conference to be held in Pisa, Italy, on September 27-30.
February 2017. Researchers at Fratagene Therapeutics, in collaboration with researchers at the Department of Biomedicine and Prevention of the University of Rome “Tor Vergata”, have identified the enzyme RNF126 as a new therapeutic target for Friedreich ataxia. The investigators found that RNF126 is the ubiquitin E3 ligase responsible for the degradation of frataxin. Molecular strategies aimed at the inhibition of RNF126 would pave the way to the development of a new class of drugs able to prevent frataxin degradation, thus restoring frataxin levels in patients and providing hope of cure. The results of this work have been published in Cell Reports.
January 2017. Fratagene Therapeutics to fully support the salary of one investigator, that will establish in vitro cultures of sensory neurons, differentiated form iPSC derived from Freidreich ataxia patients, as a cellular disease model.
November 2016. Fratagene Therapeutics to fully support the salary of one investigator, that will be involved in the analysis of frataxin modifications, at the Department of Biomedicine and Prevention, University of Rome “Tor Vergata”
October 2016. Dr. Mark Pook, Brunel University, London UK and Dr. Javier Santos, IQUIFIB, University of Buenos Aires, Argentina, have joined the Scientific Advisory Board. Dr. Pook developed some of the best animal models for Friedreich ataxia currently available. Dr. Santos is among the top experts in frataxin structure and dynamics.
August 2016. Fratagene Therapeutics to fully support the salary of two investigators, that will be involved in research projects concerning the modulation of frataxin ubiquitination and phosphorylation as possible therapeutic strategies for Friedreich ataxia, at the Department of Biomedicine and Prevention, University of Rome “Tor Vergata”.
July 2016. Fratagene Therapeutics to fund, with 0.5 M euros, research programs combining both drug discovery and drug repositioning approaches, that may lead to new therapies for Friedreich ataxia, within the premises of the Department of Biomedicine and Prevention, University of Rome “Tor Vergata”.
June 2016. Fratagene Therapeutics and the University of Rome “Tor Vergata” enter a framework agreement aimed at supporting the discovery and development of new therapies for Friedreich ataxia.
April 2016. Fratagene Therapeutics and Colosseum Combinatorial Chemistry Centre for Technology, Rome, team to develop small molecules that could act as inhibitors of frataxin ubiquitination and degradation, as potential new drugs for Friedreich ataxia.
March 2016. Fratagene Therapeutics and SARomics Biostructures, Lund, Sweden, will collaborate to elucidate structure-function relationships of the E3 ligase responsible for frataxin ubiquitination, a potential therapeutic target for Friedreich ataxia.
February 2016. Fratagene Therapeutics and Horizon Pharma, Dublin, Ireland, enter a license agreement on the possible use of interferon gamma as a therapeutic agent for Friedreich ataxia.
November 2015. The European Research Council awards the 2015 Proof-of-Concept Grant to Prof. Roberto Testi, as a continuation of a previously awarded Advanced Grant, to help develop a cure for Friedreich ataxia and bring it to market. Fratagene Therapeutics srl is created in Rome.